Abstract\n Shape and form of the watermelon fruits are important factors to save spaces and reducing damage during storing of the fruits. In order to save spaces and prevent fruit damage in watermelon the following experiment was carried out in the farm. The fruits were boxed when they were approximately one cm less than the box diameter. The cubic, hexagonal forms were compared in this research. To do this, different boxes were designed with different holes on the sides to holes the watermelons fruits for shaping. The shapes of the boxes were hexagonal and cubic. The boxes holes sizes were the same with 10mm diameter each. Each side of the boxes had different holes including: without holes to 75 holes. The result showed that the best shape for watermelon storing to save space and prevent fruit damage was hexagonal form. The percentages of the fruit damage were 33 to 80 respectively.

Abstract\nLiterary interaction of Persian-speaking countries and Attitudes of their poets in terms of science and research, has been of interest to researchers in recent decades and in many countries like Iran and Tajikistan have led to literary and linguistic sharing. Following the movement of Modern poetry, many Tajik poets including Farzaneh Khudjandi have been affected by Iranian poets, especially by Forough Farrokhzad. In this paper, after analyzing the background of contemporary poetry in Iran and Tajikistan, poems of Farzaneh Khudjandi and Forough Farrokhzad have been compared with each other. In this comparison the poems of two poets in terms of expression and linguistic, verbal and intellectual features, meter, content and theme have been reviewed. The theme of Foroughand Farzaneh\'spoems is reviewed in three levels of social - political, religious-ethical and emotional issues. Both poets, in terms of feminine feeling and emotion, the love and patriotism arein common and in terms of social – political attitude, man, the world, physical and heavenly love, despair and hopelessness and death are different. We see the use of literary technique as rhyme, metaphor, symmetry and intertextuality in the lyrics of Forough and Farzaneh. At the beginning, both poets had used classical meter and then Modern meter. Study and comparison of these two poets\' poems expresses that Farzaneh is deeply influenced by poem and thoughts of Forough.

The copper-zinc superoxide dismutase gene resides on chromosome 21 and is over expressed in Down syndrome patients. Reactive oxygen species can initiate lipid peroxidation and DNA damage leading to mutagenesis, carcinogenesis and cell death, if the antioxidant system is impaired. Down syndrome is associated with various forms of thyroid dysfunction, hypothyroidism being the most common. The additive effects of both co-morbid conditions lead to further amplification of the clinical problems in the children with Down syndrome. The present work aimed to study the changes in the quantitative in vitro activities of the antioxidant enzymes – glutathione peroxidase and superoxide dismutase in the erythrocyte and thyroid stimulating hormone level of the study group. This study group included both Down syndrome patients and age, sex matched healthy controls. We found significant increase in the activities of both glutathione peroxidase and superoxide dismutase and thyroid stimulating hormone level in patients as compared with healthy controls. This study has revealed that increased antioxidant enzymes activity and thyroid stimulating hormone level are the three significant indicators of Down syndrome patients.

Manufacturing and productive service industries such as urban recreation and leisure industry have contributed to capital generation during past several decades. Modernism era (19th to middle of 20th centuries) had many conceptual and symbolic differences compared to present atmosphere known as postmodern era. \nMetropolitan areas were historically recognized by the “brands” of their manufacturing industries up to the middle of 20th century. Former city functions have been replaced by new ones and urban spaces are now organized based on social and economic changes that occurred during postmodern era. Among spaces that extensively increase public consumption, create employment, and promote urban living are spaces created to provide recreational, leisure, training, and tourism services. \nPresent amusement parks are multifunctional and provide cultural, economic, and social functions. These parks provide pre and post relations various industries that supply product and services to Metropolitan areas including large industrial producers of amusement park equipments, consulting and construction companies, transport industry, and other productive service industries providing design, consulting, insurance, banking, travel, and other similar services.\nAmusement parks produce extensive social and cultural impacts. Large theme parks have turned into “global villages” that act as a crossroad for different social strata, civilizations, and nations. \nIran 1404 Outlook Document has put priority on improvement of social justice in all economic, social, and cultural programs. This document has highlighted infrastructure development for macro programming. In compliance with the directives of this document, Tehran Municipality has undertaken to construct one of the largest social and cultural projects with the participation of private sector. This huge project is named “Hezar-o-Yek Shahr” recreational complex. This complex is planned over 150,000 hectares and incorporates Islamic and Iranian cultural and architectural characteristics in its construction. “Hezar O Yek Shahr” is intended to become the focal point and serve as a model for optimization of economic, social, and cultural functions for residents of Tehran metropolitan area. \nPresent study is a practical research based on its objectives. Research methodology is analytic-descriptive. The findings of this research confirmed the effectiveness of social oriented projects in improving living quality and enrichment of leisure time subject to effective management and monitoring.

Abstract. – OBJECTIVES: The cardiotoxicity of doxorubicin limits its clinical use in the treatment of a variety of solid tumors and malignant hematologic disease. Although the mechanism by which it causes cardiac injury is not yet known, apoptosis has been regarded as one of mechanisms underlying the cardiotoxic effects of doxorubicin. In the present study, we investigates the mechanisms of doxorubicin-induced apoptosis in H9c2 cardiomyocytes by NF-κB dependant PUMA upregulation.\nMATEERIALS AND METHODS: H9c2 cardiac myocytes was treated with 5-50uM concentration of doxorubicin for 72 hours. p65 siRNA or PUMA siRNA was transfected into H9c2 cardiac myocytes ,then treated with 50 uM doxorubicin for 72 hours. Apoptotic cells were detected using Flow cytometric analysis. MTT cytotoxicity test was used to detect the effect of doxorubicin on H9c2 cardiac myocytes.PUMA expression was detected by western blot assay. NF-kappaB binding activities was detected using electrophoretic mobility shift assays (EMSA). \nRESULTS: Doxorubicin promotes apoptosis and inhibits proliferation in H9c2 cardiac myocytes in a dose and time-dependent way.Doxorubicin treatment increased NF-kappaB binding activities and PUMA expression. Inhibition of p65 by p65 siRNA decreased PUMA expression of doxorubicin-induced.Furthermore, p65 siRNA or PUMA siRNA-mediated suppression of p65 or PUMA results in inhibition of apoptosis of doxorubicin-induced. \nCONCLUSIONS: It is demonstrated that PUMA is a direct target of NF-κB and mediates doxorubicin -induced apoptosis in vitro .

Abstract. – OBJECTIVES: The cardiotoxicity of doxorubicin limits its clinical use in the treatment of a variety of solid tumors and malignant hematologic disease. Although the mechanism by which it causes cardiac injury is not yet known, apoptosis has been regarded as one of mechanisms underlying the cardiotoxic effects of doxorubicin. In the present study, we investigates the mechanisms of doxorubicin-induced apoptosis in H9c2 cardiomyocytes by NF-κB dependant PUMA upregulation.\nMATEERIALS AND METHODS: H9c2 cardiac myocytes was treated with 5-50uM concentration of doxorubicin for 72 hours. p65 siRNA or PUMA siRNA was transfected into H9c2 cardiac myocytes ,then treated with 50 uM doxorubicin for 72 hours. Apoptotic cells were detected using Flow cytometric analysis. MTT cytotoxicity test was used to detect the effect of doxorubicin on H9c2 cardiac myocytes.PUMA expression was detected by western blot assay. NF-kappaB binding activities was detected using electrophoretic mobility shift assays (EMSA). \nRESULTS: Doxorubicin promotes apoptosis and inhibits proliferation in H9c2 cardiac myocytes in a dose and time-dependent way.Doxorubicin treatment increased NF-kappaB binding activities and PUMA expression. Inhibition of p65 by p65 siRNA decreased PUMA expression of doxorubicin-induced.Furthermore, p65 siRNA or PUMA siRNA-mediated suppression of p65 or PUMA results in inhibition of apoptosis of doxorubicin-induced. \nCONCLUSIONS: It is demonstrated that PUMA is a direct target of NF-κB and mediates doxorubicin -induced apoptosis in vitro .